Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
نویسندگان
چکیده
منابع مشابه
Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
Tumor progression locus 2 (TPL-2) expression is required for efficient polarization of naive T cells to Th1 effector cells in vitro, as well as for Th1-mediated immune responses. In the present study, we investigated the potential role of TPL-2 in Th17 cells. TPL-2 was found to be dispensable for Th17 cell differentiation in vitro, and for the initial priming of Th17 cells in experimental autoi...
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Xenopus 45-kDa mitogen-activated protein (MAP) kinase kinase (MAPKK) is a serine/threonine/tyrosine kinase, which activates MAP kinase (MAPK) by phosphorylating its threonine and tyrosine residues. MAPKK is active only when its threonine and/or serine residues are phosphorylated. We have identified from Xenopus eggs two protein kinases responsible for phosphorylation of MAPKK. The two kinases a...
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On page 1677, Ruocco et al. show that the formation of bone-resorbing osteoclasts is crippled when the  subunit of the NF- B–activating I B kinase (IKK) complex is missing. The absence of IKK  also protected mice against inflammatory-induced bone loss, a complication of inflammatory diseases such as rheumatoid arthritis (RA) that is caused by excessive activation of osteoclasts. The osteoc...
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tor–associated factor (TRAF) family of adaptor proteins Activation of the transcription factor NF-kB by tumor as signal transducers (Rothe et al., 1995a; Cao et al., necrosis factor (TNF) and interleukin-1 (IL-1) requires 1996a; Hsu et al., 1996a). TRAF proteins associate dithe NF-kB-inducing kinase (NIK). In a yeast two-hybrid rectly with the cytoplasmic domain of several members screen for NI...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2010
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2010.173